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Peptide complexity: The briefing emphasized immunogenicity, self-association, aggregation, peptide-related impurities, and characterization challenges

instead, it promotes the production of endogenous glutathione in cells, thus enhancing the innate antioxidant response of cells

Dosing is individualized based on response and side effects, often starting at lower doses than those used in transplant patients

This risk posits a critical limitation on the therapeutic window for senolytic drugs like FOXO4-DRI, demanding a fine balance between efficacy and safety